Product ID:TRANDATE TABLETS 300 MG
MSDS Date:12/19/1994
FSC:6505
NIIN:01-197-4180
MSDS Number: BXPBH

Emergency Phone: 919-248-2100/919-248-2700

Info Phone: 919-248-2100/919-248-2700

Cage: 34006

Telephone: 919-248-2100

Cage: 34006

LABETALOL HYDROCHLORIDE

CAS: 32780-64-6

RTECS: CV5376000

Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:SKIN: IRRITATION & CONTACT DERMATITIS.
INHALATION/INGESTION: SYSTEMIC EFFECTS. EYES: IRRITATION.
LABETALOL-ABSORBED BY ANY ROUTE MAY CAUSE CONGESTIVE HEART
FAILURE/LIVER DAMAGE/HYPERSENSITIVITY/STROKE /OPTIC NERVE DAMAGE.
SMALL AMOUNTS ARE EXCRETED IN HUMAN MILK. LOW BLOOD PRESSURE/SLOWED
HEART RATE/ (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:LABETALOL- INFLAMMATION/ITCHING/DARK
URINE/WEIGHT LOSS/LACK OF APPETITE/JAUNDICE/DECREASED BLOOD
PRESSURE/SWEATING/FLUSHING/DIZZINESS/NUMBNESS/NAUSEA/VOMITING/RASH/
HIVES/DIFFICULTY BREATHING/ANAPHYLAX IS/SHORTNESS OF
BREATH/UNCONSCIOUSNESS/CONVULSIONS/SHOCK/CHEST PAIN/ALTERATION IN
ELECTROCARDIOGRAM/COUGHING.
Medical Cond Aggravated by Exposure:KNOWN HYPERSENSITIVITY TO
LABETALOL, IMPAIRED LIVER FUNCTION.

First Aid:EYES: FLUSH W/LARGE AMOUNTS OF COOL WATER FOR 15 MINS. SKIN:
WASH AFFECTED AREAS THOROUGHLY W/SOAP & WATER. INHALATION: GIVE
CPR/OXYGEN IF NEEDED. INGESTION: IF AWAKE & ABLE TO SWALLOW, RINSE
MOUTH W/ WATER. NEVER GIVE ANYTHING BY MOUTH IF UNCONSCIOUS/HAVING
CONVULSIONS. OBTAIN MEDICAL ATTENTION IN ALL CASES.

Extinguishing Media:WATER SPRAY, MULTI-PURPOSE DRY CHEMICAL.
Fire Fighting Procedures:WEAR SELF CONTAINED BREATHING APPARATUS & FULL
PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:BREAKAGE OF TABLETS COULD CONTRIBUTE TO
DUST FORMATION. AS W/ANY ORGANIC DUST, THERE IS POTENTIAL FOR
EXPLOSION WHEN HIGH CONCENTRATIONS ARE SUSPENDED IN AIR.

Spill Release Procedures:PROTECTIVE EQUIPMENT MAY BE NECESSARY. SMALL:
COLLECT & TRANSFER TO A CLOSED WASTE CONTAINER FOR DISPOSAL. LARGE:
COLLECT BY CAREFULLY SWEEPING/WIPING & PLACE IN A LABELLED, SEALED
CONTAINER FOR DISPO SAL. WASH AREA W/SUITABLE CLEANING SOLVENT.

Handling and Storage Precautions:STORE BETWEEN 36-86F. PROTECT FROM
EXCESSIVE MOISTURE & LIGHT.

Respiratory Protection:WEAR A NIOSH/MSHA APPROVED RESPIRATOR WHENEVER
EXPOSED TO HIGH DUST LEVELS.
Ventilation:GOOD GENERAL EXHAUST IN AREAS OF HIGH DUST CONCENTRATION.
Protective Gloves:LATEX
Eye Protection:RECOMMENDED FOR HIGH DUST CONCENTRATION
Other Protective Equipment:ADEQUATE PROTECTIVE CLOTHING.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
HEALTH HAZARDS CONT'D: LOW BLOOD SUGAR/RESPIRATORY DEPRESSION HAS BEEN
REPORTED IN INFANTS OF MOTHERS TREATED W/LABETALOL DURING
PREGNANCY. LABETALOL HYDROCHLORIDE IS A SINGLE AGENT CONTAINING
BOTH SE LECTIVE ALPHA-ADRENERGIC & NON-SELECTIVE BETA-ADRENERGIC
RECEPTOR BLOCKING ACTIONS. USED FOR CONTROL OF HYPERTENSION.

Solubility in Water:SLIGHT (LABETALOL)
Appearance and Odor:ROUND, PEACH TABLET ENGRAVED W/"TRANDATE 300
GLAXO."

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:LABETALOL-EXTREME HEAT, LIGHT, EXCESSIVE
MOISTURE.
Hazardous Decomposition Products:LABETALOL HYDROCHLORIDE-TOXIC
&/CORROSIVE VAPORS, HYDROGEN CHLORIDE & OXIDES OF NITROGEN.

Waste Disposal Methods:UNUSED PRODUCT SHOULD BE DISPOSED OF AT AN
APPROVED FACILITY IAW/FEDERAL, STATE & LOCAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.